Friday, February 29, 2008
CT Scan complete!
Thursday, February 28, 2008
Lawn Chemicals finally got me....
Tuesday, February 26, 2008
Second Opinion from Duke today!!!
Verruca cell info:
1-4% of laryngeal cancers
Has cytologic and architectural features normally associated with a reactive process, but with ability to invade normal tissue
Locally destructive, but almost never metastasizes; associated cervical adenopathy may be reactive and not metastatic disease
Usually men in 50’s to 60’s; associated with tobacco smoking or chewing
Occurs anywhere in upper aerodigestive tract
5 year survival 78% (better after surgery than radiation therapy)
May coexist with conventional squamous cell carcinoma (if both present, must treat more aggressive component)
HPV negative
Difficult diagnosis to make, particularly from biopsies
Treatment: surgery; radiation not recommended in general since ineffective and may cause anaplastic transformation
Gross: large, white-tan exophytic tumor fixed to normal structures; up to 10 cm; attached by broad base
Micro: invasive cancer with well differentiated squamous epithelium that lacks features of squamous cell carcinoma; by definition has no dysplastic features above basal zone; uniform cells without atypia or mitotic figures; marked surface keratinization (church-spire keratosis), broad rete pegs with pushing but not an infiltrative margin; may have prominent lymphoplasmacytic and histiocytic infiltrate
DD: papilloma, well differentiated squamous cell carcinoma, verrucous keratosis (no invasion), pseudoepitheliomatous hyperplasia, verrucae vulgaris, papillomatosis
